Hyperthermic Intraoperative Peritoneal Chemotherapy

Hyperthermic/ Heated Intraoperative Peritoneal Chemotherapy is administered to treat cancers that have spread to the peritoneum from cancers arising from the appendix, colon, stomach and ovaries.

Traditional chemotherapy is given through veins whereas HIPEC is delivered into the peritoneal cavity.

It is an innovative modality of giving chemotherapy that administers the chemotherapy drugs directly to the abdominal cavity.

Mechanism Of Action

HIPEC is a surgical procedure that offers new hope to patients with abdominal cancers.

It is administered after the removal of the visible tumor through cytoreductive surgery.

Surgeons administer a higher dose of heated chemotherapy agent inside the peritoneal cavity at a temperature of 108F.

It allows surgeons to enhance the cancer-fighting abilities of the drugs while directly targeting cancer cells.

The infusion is given for 90 minutes, chemotherapy drugs washed away and incisions are closed.

Advantages include fewer side effects compared to traditional chemotherapy, chemotherapy agents do not enter the systemic circulation and higher concentrations resulting in greater effectiveness in killing the cancer cells at the target site.

Indications For HIPEC

  • Gastric Cancer.
  • Colorectal cancer.
  • Malignant ascites.
  • Appendix cancer.
  • Ovarian Cancer.
  • Peritoneal Cancer.
  • Desmoplastic small round cell tumors.
  • Locally advanced cancers in the abdomen.

Who Is a Candidate for HIPEC?

The best candidates are those who have been diagnosed with:

  1. Appendix cancer
  2. Colorectal cancer
  3. Desmoplastic small round cell tumors (typically occurs in
  4. adolescents or young adults)
  5. Malignant ascites
  6. Mesothelioma
  7. Ovarian cancer
  8. Peritoneal cancer
  9. Stomach (gastric) cancer
  10. Other locally advanced cancers in the abdomen.