hipec
Hyperthermic Intraoperative Peritoneal Chemotherapy
Hyperthermic/ Heated Intraoperative Peritoneal Chemotherapy is administered to treat cancers that have spread to the peritoneum from cancers arising from the appendix, colon, stomach and ovaries.
Traditional chemotherapy is given through veins whereas HIPEC is delivered into the peritoneal cavity.
It is an innovative modality of giving chemotherapy that administers the chemotherapy drugs directly to the abdominal cavity.
Mechanism Of Action
HIPEC is a surgical procedure that offers new hope to patients with abdominal cancers.
It is administered after the removal of the visible tumor through cytoreductive surgery.
Surgeons administer a higher dose of heated chemotherapy agent inside the peritoneal cavity at a temperature of 108F.
It allows surgeons to enhance the cancer-fighting abilities of the drugs while directly targeting cancer cells.
The infusion is given for 90 minutes, chemotherapy drugs washed away and incisions are closed.
Advantages include fewer side effects compared to traditional chemotherapy, chemotherapy agents do not enter the systemic circulation and higher concentrations resulting in greater effectiveness in killing the cancer cells at the target site.
Indications For HIPEC
Gastric Cancer.
Colorectal cancer
Malignant ascites.
Appendix cancer.
Ovarian Cancer.
Peritoneal Cancer
Desmoplastic small round cell tumors.
Locally advanced cancers in the abdomen.
Who Is a Candidate for HIPEC?
Appendix cancer
Colorectal cancer
Desmoplastic small round cell tumors (typically occurs in
adolescents or young adults)
Malignant ascites
Mesothelioma
Ovarian cancer
Peritoneal cancer
Stomach (gastric) cancer
Other locally advanced cancers in the abdomen.
Bilateral SALPINGO-OOPHERECTOMY – Removal of both ovaries and tubes.